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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK
All Species:
27.58
Human Site:
S182
Identified Species:
60.67
UniProt:
P08567
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08567
NP_002655.2
350
40097
S182
Q
E
G
L
M
I
A
S
S
L
L
N
E
G
Y
Chimpanzee
Pan troglodytes
XP_515524
350
40124
S182
Q
E
G
L
M
I
A
S
S
L
L
N
E
G
Y
Rhesus Macaque
Macaca mulatta
XP_001094492
350
40060
S182
Q
E
G
L
M
I
A
S
S
L
L
N
E
G
Y
Dog
Lupus familis
XP_537486
375
42096
S207
L
E
A
V
T
L
A
S
M
L
M
E
E
N
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHK5
350
39882
A182
Q
E
G
L
M
I
S
A
S
L
L
S
E
G
Y
Rat
Rattus norvegicus
Q4KM33
350
39977
A182
Q
E
G
L
M
I
S
A
S
L
L
S
E
G
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512767
334
37917
S166
Q
E
G
L
M
I
A
S
S
L
L
S
E
G
F
Chicken
Gallus gallus
NP_990194
353
40280
S184
K
E
G
L
M
L
A
S
S
L
L
N
E
G
Y
Frog
Xenopus laevis
NP_001080021
289
33430
H155
K
D
K
K
V
F
N
H
C
F
T
G
T
C
V
Zebra Danio
Brachydanio rerio
NP_957135
352
40176
S182
T
E
A
V
M
L
A
S
G
L
L
N
E
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
T181
E
K
G
I
E
I
G
T
K
L
L
S
Q
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
36
N.A.
92
92
N.A.
80.5
81.5
63.1
67.3
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
100
100
55.7
N.A.
96.8
97.1
N.A.
89.4
90.6
73.7
83.8
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Identity:
100
100
100
33.3
N.A.
80
80
N.A.
86.6
86.6
0
60
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
60
N.A.
100
100
N.A.
100
100
20
80
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
0
0
0
64
19
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% C
% Asp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
82
0
0
10
0
0
0
0
0
0
10
82
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
28
% F
% Gly:
0
0
73
0
0
0
10
0
10
0
0
10
0
73
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
64
0
0
0
0
0
0
0
0
0
% I
% Lys:
19
10
10
10
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
10
0
0
64
0
28
0
0
0
91
82
0
0
0
10
% L
% Met:
0
0
0
0
73
0
0
0
10
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
46
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
55
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
19
64
64
0
0
37
0
0
0
% S
% Thr:
10
0
0
0
10
0
0
10
0
0
10
0
10
0
0
% T
% Val:
0
0
0
19
10
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _